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Influence of polygenic risk of schizophrenia on social functioning indicators in patients with schizophrenia and schizophrenia spectrum disorders
https://doi.org/10.25557/2073-7998.2025.06.86-88
Abstract
Schizophrenia is a polymorphic and polygenic disorder that affects all aspects of a patient’s life. Objective: To study how the polygenic scores of schizophrenia risk (SZ-PRS) are associated with the level of education and labor adaptation in patients with schizophrenia. Methods: The sample consisted of 829 patients diagnosed with schizophrenia or schizophrenia spectrum disorders. Data on the level of education and employment were available for all participants. The polygenic score of schizophrenia risk (SZ-PRS) calculated as a weighted sum of single nucleotide polymorphisms that were associated with schizophrenia in a genome-wide association study was used as an indicator of genetic predisposition to schizophrenia. General linear models were used in statistical analysis. The results of the study showed that higher SZ-PRS predicted worse employment (p=0.003) and lower educational level (p=0.09) in women, but not in men. Conclusions: The study demonstrates for the first time that genetic predisposition to schizophrenia can negatively affect patients social functioning, thereby impairing their quality of life.
Keywords
schizophrenia,
polygenic risk scores for schizophrenia (SZ-PRS),
polygenic association study (GWAS),
education,
work
Supporting agencies: The research was carried out within the state assignment of Ministry of Science and Higher Education of the Russian Federation.
About the Authors
T. V. Lezheiko
Scientific Center for Mental Health
Russian Federation
Russian Federation
34, Kashirskoe Shosse, Moscow, 115522
N. V. Kondratyev
Scientific Center for Mental Health
Russian Federation
Russian Federation
34, Kashirskoe Shosse, Moscow, 115522
V. E. Golimbet
Scientific Center for Mental Health
Russian Federation
Russian Federation
34, Kashirskoe Shosse, Moscow, 115522
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Review
For citations:
Lezheiko T.V., Kondratyev N.V., Golimbet V.E. Influence of polygenic risk of schizophrenia on social functioning indicators in patients with schizophrenia and schizophrenia spectrum disorders. Medical Genetics. 2025;24(6):86-88. (In Russ.) https://doi.org/10.25557/2073-7998.2025.06.86-88
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