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Polymorphism of cell adhesion molecules genes and undeveloped pregnancy
https://doi.org/10.25557/2073-7998.2025.06.16-21
Abstract
Introduction. Approximately one-third of all pregnancies end in early miscarriage. The highest risk period for spontaneous pregnancy loss occurs within the first 12 weeks, during which 80% of all spontaneous abortions take place. Cell adhesion molecules are key components throughout the reproductive cycle and may influence the risk of pregnancy loss.
Objective: to study the influence of gene polymorphisms CDH1 (rs16260, rs5030625), SELL (rs2229569, rs1131498), ITGB3 (rs5918), ITGA2 (rs1126643) on the risk of pregnancy loss in the first trimester in women from the Rostov region.
Methods. DNA was extracted from peripheral blood cells using a thermocoagulation method. Single nucleotide polymorphisms were analyzed by allele-specific PCR and restriction fragment length polymorphism analysis.
Results. No statistically significant differences were found in the distribution of genotypes and alleles of the studied single nucleotide polymorphisms between women with normal pregnancies and those with first-trimester pregnancy loss. In the present study, there were no statistically significant differences in the distribution of genotypes and alleles for the studied single nucleotide substitutions between women with normal pregnancy and women with miscarriage in the first trimester. However, it has been established that there is a synergy between polymorphic loci of the CDH1, SELL and ITGA2 genes.
Supporting agencies: The work was carried out with the financial support of the Ministry of Science and Higher Education of the Russian Federation within the framework of the state assignment No. FENW-2023-0018.
About the Authors
T. A. Sukhodolova
Southern Federal University
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006
E. V. Mashkina
Southern Federal University
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006
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Review
For citations:
Sukhodolova T.A., Mashkina E.V. Polymorphism of cell adhesion molecules genes and undeveloped pregnancy. Medical Genetics. 2025;24(6):16-21. (In Russ.) https://doi.org/10.25557/2073-7998.2025.06.16-21
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