Genetic factors of predisposition to hereditary forms of thrombophilia in women with high-risk pregnancy
https://doi.org/10.25557/2073-7998.2020.11.87-88
Abstract
Estimation of genetic factors that lead to risk of thromboembolic complications in pregnant women, has a great importance in current time. Investigation of gene polymorphisms of hemostatic system (F5 (G1691А), F2 (G20210A), SERPINC1(G786A), PROC(A2583T)) with application of real time polymerase chain reaction in 63 patients with aggravated obstetric anamnesis was done. It was shown that the presence in the genotype of 48 patients (76%) of one or a combination of several low-functional alleles of the studied genes is a risk factor for the development of thrombophilic pregnancy complications (fetoplacental insufficiency, threatening miscarriage, preeclampsia, premature detachment of normally situated placenta, intrauterine fetal death).
About the Authors
S. Y. Ratnikova
Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov
Russian Federation
Russian Federation
T. P. Zhukova
Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov
Russian Federation
Russian Federation
E. S. Zaytseva
Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov
Russian Federation
Russian Federation
T. G. Koneva
Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov
Russian Federation
Russian Federation
References
1. Михайлиди И.А. К вопросу о нарушениях в системе протеин С с разнообразной акушерской патологией в анамнезе у беременных. Акушерство, гинекология и репродукция 2014; 8(3): 59-62
2. Пизова Н.В., Степанова М.В. Тромбофилии, связанные с резистентностью к активированному протеину С: генетические полиморфизмы и инсульт. Неврологический журнал 2012; (6): 4-11
3. Репина М.А., Сумская Г.Ф., Лапина Е.Н., Кузьмина С.Р.- Крутецкая Особенности течения беременности у женщин с наследственными формами тромбофилии. Журнал акушерства и женских болезней 2006; LV(2): 3-9
Review
For citations:
Ratnikova S.Y., Zhukova T.P., Zaytseva E.S., Koneva T.G. Genetic factors of predisposition to hereditary forms of thrombophilia in women with high-risk pregnancy. Medical Genetics. 2020;19(11):87-88. (In Russ.) https://doi.org/10.25557/2073-7998.2020.11.87-88
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