Genetic risk factors for tuberculosis treatment effectiveness

Abstract

The prognosis of treatment for tuberculosis, as a multifactorial disease, depends on the interaction of genetic and environmental factors, therefore, the identification of genetic markers that can determine the state of immunological resistance of the body and thereby the effectiveness of its cure is promising. The results of the observation of 337 patients with various forms of pulmonary tuberculosis taking the main course of treatment are presented. Of these, 259 were determined as indicators-markers of genetic identification, allele-specific PCR variants of deletion polymorphism of the GSTM, GSTT and CYP2E1 genes.