Role of the polymorphiс variants of immune response and inflammation genes in pathogenesis of ovarian cancer in women of different ethnic origin

Ovarian cancer (OC) is one of the most common malignancyof the female reproductive system. High rates of morbidity and mortality from this type of cancer indicate the need for a deeper understanding of the molecular genetic basis of the disease, which in turn will contribute to the development of new approaches to the diagnosis and treatment of OC. Recently, when studying the pathogenesis of malignant neoplasms of the ovaries, a great interest of scientists around the world is directed to studying the role of the immune response and inflammation genes in the development of the OC. At this work presents the results of the study of the role of the polymorphic loci of the genes NFKB1 (rs28362491), IL6 (rs1800795), IL18 (rs1946518) and IL23R (rs7517847, rs10889677) in the pathogenesis of ovarian cancer in women from the Republic of Bashkortostan.The material for the work was the DNA samples of women with an established diagnosis of ovarian cancer (n = 238) and healthy individuals (n = 284). Genotyping of DNA samples was performed using polymerase chain reaction (PCR), followed by analysis of restriction fragment length polymorphism and allele-specific PCR. It has been established that the genetic markers of the risk of developing ovarian cancer for women of Russian ethnicity at premenopausal age are the genotypes rs28362491* ID in the NFKB1 gene and rs1946518 * CA in the IL18 gene. The carrier of the rs1800795 * GG genotypes in the IL6 gene and rs10889677 * CС in the IL23R gene for post-menopausal women of Tatar ethnicity is a protective factor. For Tatars with the rs10889677 * CA genotype in the IL23R postmenopausal gene, on the contrary, an increased risk of developing the disease was shown. Markers of a reduced risk of developing ovarian cancer in Russians can also include the rs1946518 * AA genotype in the IL18 gene, which was noted as a protective factor for women in both pre- and postmenopausal women, as well as in patients with this oncopathology with initial and advanced stages of the disease. A comparative analysis of the frequency distribution of alleles and genotypes of the polymorphic variant rs7517847 in the IL23R gene among patients with OC and healthy donors did not reveal statistically significant differences between the studied groups.

рак яичников, иммунная система, ядерный транскрипционный фактор NF-κB, интерлейкин-6 (IL-6), интерлейкин-8 (IL-8), интерлейкин-18 (IL-18), рецептор интерлейкина-23 (IL-23R), ovarian cancer, immune system, nuclear transcription factor NF-κB, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-18 (IL-18), interleukin-23 receptor (IL-23R)