Analysis of C667T polymorphism of MTHFR gene in women with preterm labor
https://doi.org/10.1234/XXXX-XXXX-2015-11-36-39
Abstract
An analysis of the presence of C677T mutant allele of MTHFR gene among the women with preterm labor was performed. The difference in the frequency of heterozygous C677T polymorphism in the MTHFR locus between the general groups of women with preterm labor and the controls was statistically unreliable. However, the carrier state of the homozygous mutant allele T in this locus determined increased risk of early and very early preterm labor in comparison with the control group (OR = 2.3; 95%CI 1.22-3.32). This finding indicates that this genetic marker is involved in the progression of venous thrombosis.
About the Authors
N. I. Lubchich
Republican specialized scientific-practice medical center of obstetrics and gynecology
Russian Federation
Russian Federation
K. T. Boboev
Scientific-research institute of hematology and hemotransfusiology
Russian Federation
Russian Federation
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Review
For citations:
Lubchich N.I., Boboev K.T. Analysis of C667T polymorphism of MTHFR gene in women with preterm labor. Medical Genetics. 2015;14(11):36-39. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2015-11-36-39
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