The role of SYDE1 gene regulatory sites in development predisposition to preeclampsia
https://doi.org/ 10.25557/2073-7998.2019.01.35-38
Abstract
Preeclampsia (PE) is one of the most serious hypertensive pregnancy disorders, which etiology and pathogenesis is remained poorly under- stood. Since a key role in the etiopathogenesis of PE is given to the placental tissue, the study of the gene expression variability in the pla- cental tissue and of the regulatory mechanisms of these changes is a promising approach. The purpose of this research was to characterize of the genetic architecture of PE on the basis of regulatory polymorphic variants (rSNPs) of the new SYDE1 candidate gene, identified for the first time by the results of the transcriptome analysis in placental tissue. In this work, we analyzed the two most significant rSNPs of the SYDE1 gene (rs56153523, rs8109071). The study was conducted in three ethnic groups: Buryats, Russians, Yakuts. We have detected associations of the rSNPs of SYDE1 gene with the development of preeclampsia in ethnic groups Buryat (rs56153523) and Russian (rs56153523, rs8109071).
About the Authors
V. N. Serebrova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
E. A. Trifonova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. Yu. Vorozhischeva
Novokuznetsk municipal clinical hospital № 1
Russian Federation
Russian Federation
V. A. Stepanov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Serebrova V.N., Trifonova E.A., Vorozhischeva A.Yu., Stepanov V.A. The role of SYDE1 gene regulatory sites in development predisposition to preeclampsia. Medical Genetics. 2019;18(1):35-38. (In Russ.) https://doi.org/ 10.25557/2073-7998.2019.01.35-38
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