Frequency of alleys and genotypes associated with sensitivity to anticoagulants from the group of vitamin K antagonists in the Kazakh population
https://doi.org/10.25557/2073-7998.2018.09.37-44
Abstract
The population frequency of alleles and genotypes CYP2C9*2 (rs12254292), *3 (rs9332108), *5 (rs1927465) и *6 (rs12254292); CYP2C19 (rs11187240); VKORC1 (rs9923231), (rs9934438); CYP4F2 (rs2108622); EPHX1 (rs7542242); GGCX (rs12616455); PROC (rs11887389), associated with the effectiveness of anticoagulant therapy with vitamin K antagonists in the Kazakh population was studied. Population sample was 2230 conditionally healthy Kazakhs. In the Kazakh population, the distribution of genotypes of 11 SNPs is in accordance with the Hardy-Weinberg equilibrium (p>0.05), with the exception of CYP2C9*3 (р<0.05). A comparative analysis showed that the CYP2C9*3, CYP2C9*5, CYP2C9*6, adverse alleles of the gene VKORC1 (rs9923231; rs9934438) and GGCX (rs11676382) alleles frequencies occupy an intermediate position between the previously described populations of Europe and Asia. The frequency of the minor alleles CYP2C9*2, CYP2C19, PROC (rs2069910) in the Kazakh population did not differ from the European populations, but significantly differs from the population of South Asia.
About the Authors
G. S. Svyatova
Republican State Enterprise on the right of economic management «Scientific Center of Obstetrics, Gynecology and Perinatology» of the Ministry of Health of the Republic of Kazakhstan
Russian Federation
Russian Federation
G. M. Berezina
Republican State Enterprise on the right of economic management «Scientific Center of Obstetrics, Gynecology and Perinatology» of the Ministry of Health of the Republic of Kazakhstan
Russian Federation
Russian Federation
Y. M. Miyerbekov
Joint Stock Company «National Scientific Center for Surgery. A.N. Syzganova
Russian Federation
Russian Federation
A. V. Murtazaliyeva
Republican State Enterprise on the right of economic management «Scientific Center of Obstetrics, Gynecology and Perinatology» of the Ministry of Health of the Republic of Kazakhstan
Russian Federation
Russian Federation
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Review
For citations:
Svyatova G.S., Berezina G.M., Miyerbekov Y.M., Murtazaliyeva A.V. Frequency of alleys and genotypes associated with sensitivity to anticoagulants from the group of vitamin K antagonists in the Kazakh population. Medical Genetics. 2018;17(9):37-44. (In Russ.) https://doi.org/10.25557/2073-7998.2018.09.37-44
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