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Медицинская генетика

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Применение кишечных органоидов для персонализированной диагностики и терапии муковисцидоза

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Аннотация

В последние 10 лет были разработаны биологические 3-D модельные системы in vitro длительного культивирования, схожие по структуре, выполняемым функциям и клеточному составу с разными органами, - органоиды. В настоящее время органоиды являются уникальной моделью для подбора персонализированной терапии, изучения фундаментальных процессов и заболеваний - генетических, онкологических, инфекционных. Культуры кишечных органоидов используют в качестве чувствительной тест-системы для оценки функциональной активности канала CFTR, диагностики муковисцидоза и назначения индивидуальной схемы лечения при этом заболевании.

Об авторах

А. С. Ефремова
ФГБНУ «Медико-генетический научный центр»
Россия


Т. Б. Бухарова
ФГБНУ «Медико-генетический научный центр»
Россия


Н. Ю. Каширская
ФГБНУ «Медико-генетический научный центр»
Россия


Д. В. Гольдштейн
ФГБНУ «Медико-генетический научный центр»
Россия


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Для цитирования:


Ефремова А.С., Бухарова Т.Б., Каширская Н.Ю., Гольдштейн Д.В. Применение кишечных органоидов для персонализированной диагностики и терапии муковисцидоза. Медицинская генетика. 2018;17(9):3-12.

For citation:


Efremova A.S., Bukharova T.B., Kashirskaya N.Y., Goldshtein D.V. Intestinal organoids and their application for personalized diagnostics and treatment of cystic fibrosis. Medical Genetics. 2018;17(9):3-12. (In Russ.)

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ISSN 2073-7998 (Print)