Investigation of the interrelation between polymorphisms of VEGF and MUC2 genes with a risk of developing endometriosis
https://doi.org/10.25557/2073-7998.2018.08.48-52
Abstract
The aim of the study was to search for the association of the polymorphisms +936C/T and +460C/T of the VEGF gene and polymorphisms of C(-15161)T (rs10902088) and T(-12150)C (rs10794288) of the MUC2 gene with the risk of developing genital endometriosis in the Slavic population of the North-Western Federal District. The study included 60 patients (mean age 32.1 ± 12.4 years) with a diagnosis of external genital endometriosis and 76 healthy donors (mean age 29.6 ± 9.7 years). Genotyping was carried out by real-time PCR using the LightCycler 480 Instrument II (Roche, Switzerland) amplifiers and VEGF T(-460)C (rs833061), VEGF C936T (rs3025039), MUC2 C(-15161)T (rs10902088), MUC2 T(-12150)C (rs10794288) (Sintol). The association of C allele (OR = 2.11) and the СС genotype (OR = 2.57) of polymorphism rs833061460 in VEGFA gene with an increased risk of developing external genital endometriosis in Slavic population of the North-Western Federal District.
About the Authors
D. A. Skuratovskaia
Laboratory of Immunology and Cellular Biotechnology IKBFU
Russian Federation
Russian Federation
K. A. Yurova
Laboratory of Immunology and Cellular Biotechnology IKBFU
Russian Federation
Russian Federation
N. V. Kulikova
Laboratory of Immunology and Cellular Biotechnology IKBFU
Russian Federation
Russian Federation
M. V. Afanasieva
St. Petersburg City Clinical Hospital No. 40
Russian Federation
Russian Federation
O. V. Sednev
Gynecological Department of BSMP
Russian Federation
Russian Federation
B. L. Tsivyan
St. Petersburg City Clinical Hospital No. 40
Russian Federation
Russian Federation
L. S. Litvinova
Laboratory of Immunology and Cellular Biotechnology IKBFU
Russian Federation
Russian Federation
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Review
For citations:
Skuratovskaia D.A., Yurova K.A., Kulikova N.V., Afanasieva M.V., Sednev O.V., Tsivyan B.L., Litvinova L.S. Investigation of the interrelation between polymorphisms of VEGF and MUC2 genes with a risk of developing endometriosis. Medical Genetics. 2018;17(8):48-52. (In Russ.) https://doi.org/10.25557/2073-7998.2018.08.48-52
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