ASSOCIATIONS BETWEEN POLYMORPHIC VARIANTS OF DNA REPAIR AND METABOLISM OF XENOBIOTICS GENES AND CHROMOSOME ABERRATION LEVEL IN HUMAN LYMPHOCYTES

We present data concerning frequencies of polymorphic variants of DNA repair (MLH1 (rs1799977), PMS2 (rs1805321), XRCC1 (rs25487)), cell cycle control (TP53 (rs1042522)) and metabolism of xenobiotics (Cyp2C19 (rs4244285), GSTT1 (del) и GSTM1 (del)) genes in cohort of plutonium workers and control group. Also, subgroups with vari ous levels of chromosome abnormalities are considered (with high and low levels of chromosome aberrations, aneuploidy and micronuclei). There were no signifi cant differences of allele and genotype frequencies between group of plutonium workers and control group. However, significant differences of rs1799977 MLH1 genotype frequencies was observed between subgroups with different levels of chromosome aberrations (p=0.047) and GSTT1/GSTM1 genotype frequencies between subgroups with high and low levels of aneuploidy (p=0.032). There were also differences between subgroups regarding to genotype frequencies at other loci, but insignificant. Allele frequencies differences were registered only in XRCC1 (rs25487) between subgroups with different levels of chromosome aberrations (p=0.039).

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