DECANALIZATION OF IMMUNE RESPONSE DURING THE DISPERSION OF MODERN HUMANS: THE RELATIONSHIPS OF GENETIC DIVERSITY IN IMMUNE SYSTEM GENES AND CLIMATIC AND GEOGRAPHIC FACTORS

 Allele frequencies of sevengenes contributing to cellular immune response to parasitic infections, polarization of immune response to Th2 type and associated with atopic and allergic phenotypes was studied in 15 World popu I ations. Selection of genes and populations under study was based on the hypothesis of a shift in preferential immune response balance from Th2 to Th1 type during migration of modern humans from equatorial Africa to moderate and arctic climate regions. It is suggested that this shift was due to natural selectionprocess of adapttion of populations to a new environment. We found the systematic change in frequencies of alleles involved in immune response and inflammatory reactions during the dispersion of human population from Africa. These changes may contribute to changes in a structure of common diseases and be explained by the hypothesis of canalization/decanalzation of geno-type-environment relationships occurring under the pressure of natural selection.

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