SEMA6B IS A CANDIDATE TUMOR SUPPRESSOR GENE IN THE CRITICAL CHROMOSOME REGION 19P13.3
https://doi.org/10.1234/XXXX-XXXX-2013-2-32-36
Abstract
Numerous studies indicate an extremely high rate of loss of heterozygosity on the short arm of chromosome 19, in the chromosomal segment 19p13.3, for different types of neoplasia: coion, cervical, breast cancers, myeloid leukemia. High rates of 19p13.3 loss of heterozygosity suggest that it contains one or more tumor suppressor genes. Our study of molecular pathology of the SEMA6B gene located in a critical area in breast cancer samples reveals features characteristic of the tumor suppressor gene. The frequency of abnormal methylation of the 5' region of the gene and the rate of loss of heterozygosity in breast cancer samples equal correspondingly 38% and 50%. A germinal mutation in an evolutionarily conserved region of the SEMA6B gene was detected in one of the breast cancer patients.
About the Authors
E. B. Kuznetsova
Research Centre for Med i cal Genetics;I.M. Sechenov 1st MSMU, Russian Health Ministry
Russian Federation
Russian Federation
E. A. Pudova
Central Research Institute of Epidemiology, Russian Inspectorate for Protection of Consumer Rights and Human Welfare
Russian Federation
Russian Federation
A. S. Tanas
Research Centre for Med i cal Genetics;I.M. Sechenov 1st MSMU, Russian Health Ministry
Russian Federation
Russian Federation
D. V. Zaletaev
Research Centre for Med i cal Genetics;I.M. Sechenov 1st MSMU, Russian Health Ministry
Russian Federation
Russian Federation
V. V. Strelnikov
Research Centre for Med i cal Genetics;I.M. Sechenov 1st MSMU, Russian Health Ministry
Russian Federation
Russian Federation
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Review
For citations:
Kuznetsova E.B., Pudova E.A., Tanas A.S., Zaletaev D.V., Strelnikov V.V. SEMA6B IS A CANDIDATE TUMOR SUPPRESSOR GENE IN THE CRITICAL CHROMOSOME REGION 19P13.3. Medical Genetics. 2013;12(2):32-36. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2013-2-32-36
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