Association of G1378T rs4961 variant of ADD1 gene with the risk of preeclampsia: a meta-analysis

Introduction. Preeclampsia is one of the most common obstetric problems, accounting for almost 15% of pregnancy-related pathologies. Various studies have evaluated the association of G1378T rs4961 variant in ADD1 gene with the risk of preeclampsia. However, results remain contradictory.

Aim. To examine the association of the ADD1 rs4961 genetic variant with the risk of preeclampsia through meta-analysis.

Methods. By searching according to the PRISMA protocol in the PubMed database, Google scholar search engine and the Russian scientific electronic library CyberLeninka.ru data on rs4961 variant of ADD1 gene in preeclampsia were collected from 8 studies. The ReviewManager (RevMan) 5.4 software was used to conduct meta-analysis. To assess the association of rs4961 variant of ADD1 gene with the risk of preeclampsia, odds ratio (OR) with a 95% confidence interval (CI) at allelic, dominant, and recessive models was calculated.

Results. No significant associations were found at any of these models: G versus T (OR = 1.55; 95% CI: 0.93, 2.58, P = 0.09), GG + GT versus TT (OR = 1.63; 95% CI: 0.96, 2.75, P = 0.07) and GG versus GT + TT (OR = 1.47; 95% CI: 0.92, 2.33, P = 0.10). Subgroup analysis revealed a statistically significant association between the ADD1 gene variant rs4961 and the risk of developing preeclampsia in Russian populations. The presence of the (TT) genotype doubles the risk of preeclampsia (OR = 2.07; 95 % CI: 1.00, 4.30, P = 0.05).

Conclusions. The results of the meta-analysis indicate no association between the ADD1 gene variant rs4961 and preeclampsia. However, subgroup analysis revealed that the (TT) genotype is associated with a high risk of preeclampsia in the Russian population. This suggests that the effect of the rs4961 variant on the pathogenesis of preeclampsia exhibits population specific characteristics. 

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