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Genetic profile of Russians from the Siberian region based on a study of genes determining the inflammatory response
https://doi.org/10.25557/2073-7998.2026.02.63-66
Abstract
The development and control of inflammation are governed by intracellular signaling pathways that form a multicomponent network regulatory structure. The efficiency of interaction between individual elements of this network can be modified by various factors, including genetic polymorphism. This article discusses the results of a study conducted in a sample of the Russian population of the Siberian region (n = 192), focusing on the spectrum and frequencies of polymorphic variants of the VDR and NFKB1 genes and their functional partners — 33 polymorphic variants across 11 genes. The study identified 283 complexes of polymorphic variants in the «vitamin D – VDR» system genes (including 4 with a frequency >1%) and 154 complexes in the «NF-kB1 – 20S proteasome» system genes (20 with a frequency >1%).
Supporting agencies: The work was carried out within the framework of the state assignment of the Ministry of Health of the Russian Federation for KemSMU (Agreement No. 056-03-2023-050 dated 01/17/2023) and a grant from the Russian Science Foundation (No. 22-25-20209, https://rscf.ru/ project/22-25-20209) and the Ministry of Science and Higher Education of Kuzbass.
About the Authors
M. B. Lavryashina
Kemerovo State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
22а, Voroshilova st., Kemerovo, 650056, Russian Federation
B. A. Tkhorenko
Kemerovo State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
22а, Voroshilova st., Kemerovo, 650056, Russian Federation
A. V. Meyer
Kemerovo State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
22а, Voroshilova st., Kemerovo, 650056, Russian Federation
A. A. Korostelev
Kemerovo State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
22а, Voroshilova st., Kemerovo, 650056, Russian Federation
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Review
For citations:
Lavryashina M.B., Tkhorenko B.A., Meyer A.V., Korostelev A.A. Genetic profile of Russians from the Siberian region based on a study of genes determining the inflammatory response. Medical Genetics. 2026;25(2):63-66. (In Russ.) https://doi.org/10.25557/2073-7998.2026.02.63-66
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