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Pathogenetics of co-occurrence of bronchial asthma with cardiovascular, allergic and infectious diseases.
https://doi.org/10.25557/2073-7998.2025.12.110-112
Abstract
The structure of diseases is heterogeneous, which is manifested by various combinations of diseases, including comorbidities, as well as diseases that rarely manifest together. The aspects of genetic susceptibility to a co-occurrence of bronchial asthma (BA) with atopic dermatitis (AD), allergic rhinitis (AR), and hypertension (HD) were studied. The associations of polymorphic variants of candidate genes with the development of tuberculosis (TB), a disease rarely manifesting together in patients with allergic BA, were assessed. The features of the pathogenetics of the co-occurrence (syntropy) of BA with AD, AR, and HD, as well as the rare co-occurrence (dystropy) of BA with TB, were established.
Keywords
Supporting agencies: The research was supported by the Ministry of Science and Higher Education (No. 122020300041-7).
About the Authors
Е. Yu. Bragina
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Россия
Россия
I. А. Goncharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of SciencesFreidin М.B
Россия
Россия
М. B. Freidin
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Россия
Россия
N. P. Babushkina
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Россия
Россия
I. Zh. Zhalsanova
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Россия
Россия
М. S. Nasarenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of the Russian Federation
Россия
Россия
V. P. Puzyrev
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of the Russian Federation
Россия
Россия
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Review
For citations:
Bragina Е.Yu., Goncharova I.А., Freidin М.B., Babushkina N.P., Zhalsanova I.Zh., Nasarenko М.S., Puzyrev V.P. Pathogenetics of co-occurrence of bronchial asthma with cardiovascular, allergic and infectious diseases. Medical Genetics. 2025;24(12):110-112. (In Russ.) https://doi.org/10.25557/2073-7998.2025.12.110-112
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