Mitochondrial DNA polymorphism in advanced carotid atherosclerosis: protective effect of haplogroup J
Abstract
MtDNA polymorphism was studied in the group of patients with advanced carotid atherosclerosis and in controls with subclinical atherosclerosis. Frequencies of main European mtDNA haplogroups were determined. Comparison of the haplogroups frequencies has revealed higher frequency of haplogroup J in controls (17.65%) than in patients (4.55%; p = 0.0145). The results suggest protective effect of haplogroup J in relation to advanced carotid atherosclerosis.
About the Authors
M. V. Golubenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Research Institute for Complex Issues of Cardiovascular diseases
Russian Federation
Russian Federation
N. V. Tarasenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
O. A. Makeeva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
I. A. Goncharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Research Institute for Complex Issues of Cardiovascular diseases
Russian Federation
Russian Federation
A. V. Markov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. A. Sleptsov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. A. Komar
Siberian State Medical University
Russian Federation
Russian Federation
M. S. Nazarenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Research Institute for Complex Issues of Cardiovascular diseases; Siberian State Medical University
Russian Federation
Russian Federation
O. L. Barbarash
Research Institute for Complex Issues of Cardiovascular diseases
Russian Federation
Russian Federation
V. P. Puzyrev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Golubenko M.V., Tarasenko N.V., Makeeva O.A., Goncharova I.A., Markov A.V., Sleptsov A.A., Komar A.A., Nazarenko M.S., Barbarash O.L., Puzyrev V.P. Mitochondrial DNA polymorphism in advanced carotid atherosclerosis: protective effect of haplogroup J. Medical Genetics. 2017;16(10):26-28. (In Russ.)
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