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Genetic and Environmental Factors of Social Adaptation in Schizophrenia: The Role of OXTR, AGER, and Adverse Childhood Experiences
https://doi.org/10.25557/2073-7998.2025.07.68-71
Abstract
Background. Social functioning is an important aspect of schizophrenia, affecting patient’s quality of life and prognosis. Genetic factors, including OXTR and AGER gene polymorphisms, potentially participate in the regulation of social behavior by interacting with adverse childhood experiences (ACEs).
Aim: to evaluate the contribution of OXTR rs1042778 and AGER rs1800625 polymorphisms to the development of social disadaptation in patients with schizophrenia, with the effect of AСEs taken into account.
Methods. A sample of 507 patients with schizophrenia were included in the study. Social functioning was assessed using the PSP scale, clinical symptoms were assessed using the PANSS. OXTR rs1042778 was genotyped using HRM method, AGER rs1800625 determined based on genome-wide genotyping data. Statistical analysis was performed using ANCOVA, adjusting for gender and disease duration.
Results. The association of AGER rs1800625 polymorphism with more prominent social deficit in the area of disturbing and aggressive behavior was revealed. A combined effect of OXTR rs1042778 and AGER rs1800625 polymorphisms was observed in relation to the level of prosocial behavior.
Conclusion. The results obtained confirm the role of AGER rs1800625 and OXTR rs1042778 in the regulation of social functioning in schizophrenia, opening prospects for further study of the interaction of genetic and environmental factors.
Keywords
Supporting agencies: The research was carried out within the state assignment of Ministry of Science and Higher Education of the Russian Federation.
About the Authors
V. A. Mikhailova
Mental Health Research Center
Russian Federation
Russian Federation
34, Kashirskoe shosse, Moscow, 115522
T. V. Lezheiko
Mental Health Research Center
Russian Federation
Russian Federation
34, Kashirskoe shosse, Moscow, 115522
V. V. Plakunova
Mental Health Research Center
Russian Federation
Russian Federation
34, Kashirskoe shosse, Moscow, 115522
V. E. Golimbet
Mental Health Research Center
Russian Federation
Russian Federation
34, Kashirskoe shosse, Moscow, 115522
References
1. Escandell M.J.., Prat G, Garcia-Franco M., et al. Clinical symptoms and social functioning in schizophrenia. Rev Psiquiatr Salud Ment (Engl Ed). 2022;15(4):251-258. doi: 10.1016/j.rpsmen.2020.05.003.
2. Mikhailova V.A., Lezheiko T.V., Kolesina N.Y., Golimbet V.E. Studies of the Relationship between Oxytocinergic System Genes, Perinatal Complications, and the Formation of Interpersonal Relationships in Schizophrenia Patients. Neurosci Behav Physiol. 2022;52(5):614-618.
3. Mikhailova V., Alfimova M., Lezheiko T., et al. The impact of the oxytocin receptor gene (OXTR) on facial affect recognition in psychosis. Eur Psychiatry. 2022;65(S1):S197-S197.
4. Munesue S.I., Liang M., Harashima A., et al. Transport of oxytocin to the brain after peripheral administration by membrane-bound or soluble forms of receptors for advanced glycation end-products. J Neuroendocrinol. 2021;33(3):e12963. doi:10.1111/jne.12963
5. Higashida H., Gerasimenko M., Yamamoto Y. Receptor for advanced glycation end-products and child neglect in mice: A possible link to postpartum depression. Compr Psychoneuroendocrinol. 2022;11:100146. doi:10.1016/j.cpnec.2022.100146
6. Alfimova M.V., Korovaitseva G.I., Gabaeva M.V., et al. Geneticheskii polimorfizm tsitokinov IL-1β, IL-4 i TNF-α kak faktor, modifitsiruyushchii vliyanie neblagopriyatnogo detskogo opyta na simptomatiku shizofrenii [Genetic polymorphism of cytokines IL-1β, IL-4 and TNF-α as a factor modifying the impact of childhood adversity on schizophrenia symptoms]. Zh Nevrol Psikhiatr Im S S Korsakova [S.S. Korsakov Journal of Neurology and Psychiatry]. 2022;122(9):110-117. (In Russ.)
7. Julian M.M., King A.P., Bocknek E.L., et al. Associations between oxytocin receptor gene (OXTR) polymorphisms, childhood trauma, and parenting behavior. Dev Psychol. 2019;55(10):2135-2146. doi: 10.1037/dev0000783.
8. Onitsuka T., Hirano Y., Nemoto K., et al. Trends in big data analyses by multicenter collaborative translational research in psychiatry. Psychiatry Clin Neurosci. 2022;76(1):1-14. doi:10.1111/pcn.13311
Review
For citations:
Mikhailova V.A., Lezheiko T.V., Plakunova V.V., Golimbet V.E. Genetic and Environmental Factors of Social Adaptation in Schizophrenia: The Role of OXTR, AGER, and Adverse Childhood Experiences. Medical Genetics. 2025;24(7):68-71. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07.68-71
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