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The role of antioxidant system and DNA repair genes polymorphic variants in breast cancer development in women
https://doi.org/10.25557/2073-7998.2025.06.40-42
Abstract
Breast cancer (BC) ranks first in the world among oncological disorders in women. Aim of the study – to perform analysis of contribution of catalase gene polymorphic variant CAT-21 A>T rs7943316 and DNA repair genes: XPD 2251 T>G rs13181, ADPRT 2285 T>C rs11610, hOGG1 977 C>G rs1052133 in breast cancer risk development in women. 298 samples of peripheral blood were collected from women with breast cancer and 287 samples as controls were used. Analysis showed significance of combinations of CAT-21 A>T rs7943316 and XPD 2251 T>G rs13181 genotypes: OR-3.02(1.15-7.92). It was demonstrated ability for formation of breast cancer risk via combination of certain genotypes of antioxidant and DNA repair genes.
Supporting agencies: This study was funded by the state task АААА-А21-121011590009-9 «Immune and hormonal interactions in breast cancer».
About the Authors
V. Yu. Buslaev
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
18, Sovietskiy st., Kemerovo, 650065
V. I. Minina
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences; Кеmerovo State University
Russian Federation
Russian Federation
18, Sovietskiy st., Kemerovo, 650065; 6, Krasnaya st., Kemerovo, 650000
R. A. Titov
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences; Кеmerovo State University
Russian Federation
Russian Federation
18, Sovietskiy st., Kemerovo, 650065; 6, Krasnaya st., Kemerovo, 650000
M. L. Bakanova
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
18, Sovietskiy st., Kemerovo, 650065
N. A. Gavrineva
Кеmerovo State University
Russian Federation
Russian Federation
6, Krasnaya st., Kemerovo, 650000
A. N. Glushkov
The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
18, Sovietskiy st., Kemerovo, 650065
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Review
For citations:
Buslaev V.Yu., Minina V.I., Titov R.A., Bakanova M.L., Gavrineva N.A., Glushkov A.N. The role of antioxidant system and DNA repair genes polymorphic variants in breast cancer development in women. Medical Genetics. 2025;24(6):40-42. (In Russ.) https://doi.org/10.25557/2073-7998.2025.06.40-42
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