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Analysis of rs113488022 polymorphism of the BRAF gene in women from the Republic of Bashkortostan
https://doi.org/10.25557/2073-7998.2025.06.27-29
Abstract
Introduction. The absence of pathognomonic symptoms and effective early screening methods of ovarian cancer dictates the need for search new molecular genetic markers of this disease.
Aim: to find the polymorphic variant rs113488022/BRAF in women from the Republic of Bashkortostan.
Methods. This study included DNA samples from women with sporadic ovarian cancer (n=210), hereditary ovarian cancer (n=72), and women without oncopathology (n=208). Genotyping was performed using real-time PCR.
Results. No carriers of the minor allele of the polymorphic locus rs113488022 of the BRAF gene were identified among the women included in the study.
Conclusions. The absence of carriers of the rare allele rs113488022/BRAF may be explained by the low prevalence of this polymorphism in the region, highlighting the need for further genetic research to identify other potential genetic predictors of ovarian cancer.
Supporting agencies: The work was carried out according to the state assignment of the Ministry of Science and Higher Education of the Russian Federation No. 075-03-2024-123/1.
About the Authors
E. A. Andreeva
Ufa State University of Science and Technology; Ural Medical Institute
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076; 9, Kurchatov st., Chelyabinsk, 454092
E. T. Aminova
Ufa State University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
Y. V. Valova
Ufa State University of Science and Technology; Ufa Research Institute of Occupational Health and Human Ecology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076; 94, Stepan Kuvykin st., Ufa, 450106
A. R. Romanova
Bashkir State Medical University
Russian Federation
Russian Federation
3, Lenin st., Ufa, 450008
R. R. Faiskhanova
Republican Clinical Oncology Dispensary
Russian Federation
Russian Federation
73/1, Oktyabrsky st., Ufa, 450054
I. R. Zagitov
Republican Clinical Oncology Dispensary
Russian Federation
Russian Federation
73/1, Oktyabrsky st., Ufa, 450054
Y. V. Babushkin
Clinical Polyclinic №8 of Chelyabinsk
Russian Federation
Russian Federation
3, Lenina pr., Chelyabinsk, 454007
E. K. Khusnutdinova
Ufa State University of Science and Technology; Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076; 71, Oktyabrsky st., Ufa, 450054
D. S. Prokofyeva
Ufa State University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076
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Review
For citations:
Andreeva E.A., Aminova E.T., Valova Y.V., Romanova A.R., Faiskhanova R.R., Zagitov I.R., Babushkin Y.V., Khusnutdinova E.K., Prokofyeva D.S. Analysis of rs113488022 polymorphism of the BRAF gene in women from the Republic of Bashkortostan. Medical Genetics. 2025;24(6):27-29. (In Russ.) https://doi.org/10.25557/2073-7998.2025.06.27-29
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