Polymorphism of genes of folate cycle in women of the Ural region and recurrent pregnancy losses
Abstract
Testing for inherited predisposition to miscarriage is an important task of genetic counseling in reproduction. One of the factors of miscarriage is deficiency of folic acid and b vitamins together with the gene polymorphism of the folate cycle. The purpose of the study was to analyze the frequency of polymorphic alleles and genotypes of genes of folate cycle in women of the Ural region and miscarriage the first trimester of pregnancy. Materials and methods. The main group consisted of 53 women with recurrent miscarriage first trimester, the comparison group of 117 women who had no cases of miscarriage in anamnesis, having one or more healthy children. All women were analyzed the following polymorphisms: MTHFR 677 C>T, MTHFR 1298 A>C, MTRR 66 A>G, MTR 2756 A> G. Results. In the group of women with recurrent pregnancy losses significantly more common genotype MTRR 66АА that defines the synthesis of the active form of the enzyme MTRR (OR = 2,44, CL95% from 1.06-5,64, p = 0.035) compared to reproductive to women in the comparison group. Frequency of polymorphic alleles and genotypes of polymorphisms MTR 2756 A>G, MTHFR 677С>T and 1298 A>C in women of the Ural region are within the boundaries of the global data and close to the estimates shown for Caucasians, and far removed from the Mongoloid population.
About the Authors
T. B. Tretyakova
Urals Scientific Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
N. S. Demchenko
Urals Scientific Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
N. E. Rukosuev
Urals Scientific Research Institute for Maternal and Child Care
Russian Federation
Russian Federation
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Review
For citations:
Tretyakova T.B., Demchenko N.S., Rukosuev N.E. Polymorphism of genes of folate cycle in women of the Ural region and recurrent pregnancy losses. Medical Genetics. 2017;16(5):42-47. (In Russ.)
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