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Медицинская генетика

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Эпигенетическое репрограммирование ДНК в гаметах и доимплантационных эмбрионах человека

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Аннотация

В обзоре приведены новые данные об эпигенетическом репрограммировании генома в гаметогенезе и доимплантационном эмбриогенезе человека. Суммированы современные представления о динамических изменениях метилирования цитозина ДНК - ключевого механизма эпигенетической регуляции генома - в гаметах и у эмбрионов доимплантационных стадий развития. Рассмотрены различия в динамике и механизмах репрограммирования импринтированных и неимпринтированных участков ДНК в мужских и женских половых клетках.

Об авторах

А. В. Тихонов
НИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта; Санкт-Петербургский государственный университет; Диагностический центр (медико-генетический)
Россия


О. А. Ефимова
НИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта; Санкт-Петербургский государственный университет
Россия


А. А. Пендина
НИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта; Санкт-Петербургский государственный университет; Диагностический центр (медико-генетический)
Россия


В. С. Баранов
НИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта; Санкт-Петербургский государственный университет
Россия


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Для цитирования:


Тихонов А.В., Ефимова О.А., Пендина А.А., Баранов В.С. Эпигенетическое репрограммирование ДНК в гаметах и доимплантационных эмбрионах человека. Медицинская генетика. 2017;16(5):17-25.

For citation:


Tikhonov A.V., Efimova O.A., Pendina A.A., Baranov V.S. Epigenetic reprogramming in human gametes and preimplantation embryos. Medical Genetics. 2017;16(5):17-25. (In Russ.)

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