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Comparative study of the complex of ribosomal genes in peripheral blood cells of patients with catatonic and paranoid forms of schizophrenia
https://doi.org/10.25557/2073-7998.2025.01.23-33
Abstract
For the first time, a comparative study of the characteristics of the ribosomal gene complex (rDNA) in the blood cells of patients with catatonic and paranoid schizophrenia and a control sample was conducted. The study involved patients with schizophrenia who live in Moscow and the Moscow region and were treated for an exacerbation of the disease at the N.A. Alekseev Psychiatric Clinical Hospital No. 1 of the Moscow City Health Department. Two groups were formed: catatonic schizophrenia (N 124); diagnosis (ICD-10): F20.2; a group of patients with the paranoid form of schizophrenia (N 450), (F20.0) and a control group (N = 240) – mentally healthy people. The level of rDNA and nuclear DNA damage (flow cytometry), the number of rDNA copies in a cell (non-radioactive hybridization), the level of rDNA transcription and the amount of 18S rRNA (RT-PCR) were determined. Catatonia is associated with higher levels of rDNA and DNA damage and higher levels of rDNA and 18S rRNA in the blood cells of patients. It is suggested that increased levels of ribosome biogenesis, including higher levels of rDNA copies in the cells of patients with catatonia, are necessary for an effective response to higher oxidative stress.
Supporting agencies: The study was carried out with financial support within the framework of the search topic N 123052200003-6
About the Authors
O. N. Agafonova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115522
E. S. Ershova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115522
A. V. Martynov
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115522
T. A. Salimova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115522
G. P. Kostyuk
Psychiatric Hospital no. 1 Named after N.A. Alexeev of the Department of Health of Moscow
Russian Federation
Russian Federation
2, Zagorodnoye shosse, Moscow, 117152
N. V. Zakharova
V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, The Institute of Personalized Psychiatry and Neurology
Russian Federation
Russian Federation
3, Bekhtereva st., St Petersburg, 192019
N. N. Veiko
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115522
S. V. Kostyuk
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115522
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Review
For citations:
Agafonova O.N., Ershova E.S., Martynov A.V., Salimova T.A., Kostyuk G.P., Zakharova N.V., Veiko N.N., Kostyuk S.V. Comparative study of the complex of ribosomal genes in peripheral blood cells of patients with catatonic and paranoid forms of schizophrenia. Medical Genetics. 2025;24(1):23-33. (In Russ.) https://doi.org/10.25557/2073-7998.2025.01.23-33
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