Lack of association of rs6339 polymorphism of the neurotrophic tyrosine kinase receptor 1 with schizophrenia in Armenian population
Abstract
Schizophrenia is a multifactorial polygenic disease characterized by both genetic and environmental components. There is growing information about the genetic variations contributing to schizophrenia. In the current study we aimed to explore the potential association of single nucleotide polymorphism rs6339 of the NTRK1 gene with schizophrenia. For this purpose, DNA samples isolated from the blood of patients with schizophrenia and healthy individuals were genotypes using polymerase chain reaction with allele-specific primers. The obtained results demonstrated no association between schizophrenia development risk and the studied genetic variant. However, the absence of association found in this study does not exclude the association of other genetic polymorphisms of this gene or nearby locus with schizophrenia.
About the Authors
R. V. Zakharyan
Institute of Molecular Biology of the National Academy of Sciences of the Republic of Armenia
Russian Federation
Russian Federation
E. H. Telumyan
Institute of Molecular Biology of the National Academy of Sciences of the Republic of Armenia
Russian Federation
Russian Federation
A. P. Gevorgyan
Diagnosic medical center «Alfa betta»
Russian Federation
Russian Federation
A. A. Arakelyan
Institute of Molecular Biology of the National Academy of Sciences of the Republic of Armenia
Russian Federation
Russian Federation
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Review
For citations:
Zakharyan R.V., Telumyan E.H., Gevorgyan A.P., Arakelyan A.A. Lack of association of rs6339 polymorphism of the neurotrophic tyrosine kinase receptor 1 with schizophrenia in Armenian population. Medical Genetics. 2017;16(4):40-43. (In Russ.)
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