The relationship between polymorphism I462V of the CYP1A1 gene and -9-154C>A of the CYP1A2 gene and colorectal cancer risk in the population of Central Russia

Colorectal cancer (CRC) is one of the most common tumors associated with high mortality in patients. The system of xenobiotics biotransformation mediated by genetic mechanisms is involved in the pathogenesis of colorectal cancer. The aim of this study was to investigate the association of polymorphisms I462V of the CYP1A1 gene and -9-154C>A of the CYP1A2 gene with the risk of CRC in population of the Central Russia. We studied DNA samples obtained from 543 subjects, including 262 CRC patients and 281 sex- and age-matched healthy individuals. The polymorphisms were genotyped through a real-time PCR using TaqMan allele-discrimination assays. We found that the genotype 462II (OR = 1,74, 95% CI = 1,02-2.97, P = 0,04) of the CYP1A1 gene was associated with increased risk of CRC. Meanwhile we observed the protective effect of 462IV genotype against the risk of CRC development (OR = 0,55, 95% CI = 0,32-0,96, P = 0,03). The comparative analysis showed no differences in allele and genotype frequencies of the CYP1A2 -9-154C>A polymorphism between cases and controls. Thus, we found that polymorphism I462V оf the CYP1A1 gene is associated with CRС in the Russian population.

Колоректальный рак, наследственная предрасположенность, биотрансформация ксенобиотиков, CYP1A1, CYP1A2, Colorectal cancer, genetic predisposition, biotransformation of xenobiotics, CYP1A1, CYP1A2

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