Polymorphism +1675G>A in gene encoding AGTR2 is associated with the development of ischemic stroke
Abstract
The renin-angiotensin system is a major regulator of blood pressure. The aim of this study was to investigate the association of polymorphisms +1675G>A (rs1403543) of AGTR2 gene with the risk of ischemic stroke (IS) in the population of Central Russia. We studied DNA samples obtained from 717 subjects, including 414 IS patients and 303 sex- and age-matched healthy individuals. The polymorphisms were genotyped by polymerase chain reaction TaqMan allele discrimination (+1675G>A) assays. The gender-stratified analysis showed that +1675AA genotype associated with an increased risk of ischemic stroke in women (OR = 2,09; 95%CI 1,20-3,62, p = 0,01) while the heterozygous +1675GA genotype associated with a reduced risk of IS (OR = 0,49 95% CI from 0,31-0,78; p = 0.002). This study was the first to demonstrate the association of the +1675G>A (rs1403543) polymorphism of AGTR2 gene with the risk of ischemic stroke in woman from Central Russia.
About the Authors
T. A. Stetskaya
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
V. O. Soldatov
Kursk State Medical University
Russian Federation
Russian Federation
A. E. Biryukov
Kursk Regional Hospital
Russian Federation
Russian Federation
V. B. Laskov
Kursk State Medical University
Russian Federation
Russian Federation
V. P. Ivanov
Kursk State Medical University
Russian Federation
Russian Federation
O. Yu. Bushueva
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Stetskaya T.A., Polonikov A.V., Soldatov V.O., Biryukov A.E., Laskov V.B., Ivanov V.P., Bushueva O.Yu. Polymorphism +1675G>A in gene encoding AGTR2 is associated with the development of ischemic stroke. Medical Genetics. 2017;16(3):33-36. (In Russ.)
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