NOS1 gene polymorphism and risk of postpartum hemorrhage in Uzbek women
https://doi.org/10.25557/2073-7998.2024.04.16-24
Abstract
Background. Given the increasing prevalence of postpartum hemorrhage, a lot of work has been done today on the pathogenesis of uterine atony. Nevertheless, the study and search for candidate genes involved in the development of uterine atony remain relevant.
Objective: to evaluate association of the genetic polymorphism NOS1 rs41279104 with myometrial dysfunction and the risk of postpartum uterine atony in Uzbek women.
Methods. We examined 101 women who developed postpartum atonic bleeding of varying severity. Common laboratory and instrumental examinations were performed on all women. Genomic DNA was used for the detection of the NOS1 rs41279104.
Results. Allele A is the risk factor for postpartum uterine atony more than 1.7 times (χ2 = 4.2, OR = 1.7, p = 0.05) in parturient women with a gestational age of 37-42 weeks. Conclusion. The results of our research indicate that the NOS1 rs41279104 has an association with postpartum atonic bleeding. In women with 37-42 weeks of gestation, allelic variant A may be a risk factor for PPH.
About the Authors
U. A. Ashurova
Tashkent Medical Academy
Uzbekistan
Uzbekistan
2, Forobiy st., Tashkent, 100109
D. K. Najmutdinova
Tashkent Medical Academy
Uzbekistan
Uzbekistan
2, Forobiy st., Tashkent, 100109
K. T. Boboev
Republican Specialized Scientific Practical Medical Center of Hematology
Uzbekistan
Uzbekistan
16/1А, Arnasay st., Chilanzar district, Tashkent, 100115
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Review
For citations:
Ashurova U.A., Najmutdinova D.K., Boboev K.T. NOS1 gene polymorphism and risk of postpartum hemorrhage in Uzbek women. Medical Genetics. 2024;23(4):16-24. (In Russ.) https://doi.org/10.25557/2073-7998.2024.04.16-24
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