Genetic Associations between polymorphic loci in the antioxidant enzyme genes GPX4 (rs713041), GSTP1 (rs1695), and PON1 (rs662) and Polycystic Ovary Syndrome in Russian women
https://doi.org/10.25557/2073-7998.2024.03.21-30
Abstract
Background. Polycystic ovary syndrome (PCOS) is a common and complex endocrinologic disease, with various molecular phenotypes and comorbid conditions. Numerous studies have highlighted oxidative stress as a pivotal factor in the development of PCOS.
Aim: to investigate the associations between polymorphic loci of the genes of antioxidant defense enzymes GPX4 (rs713041), GSTP1 (rs1695) and PON1 (rs662) and the risk of developing PCOS.
Methods. Genotyping analysis was performed by allele-specific method using real-time PCR.
Results. Genotyping analysis revealed that the minor alleles of GPX4 (rs713041) and PON1 (rs662) polymorphic loci were associated with an increased risk of PCOS development. Specifically, the presence of the TT genotype of GPX4 (rs713041) and having at least one copy of the mutant allele of PON1 (rs662) were associated with elevated susceptibility to PCOS.
Conclusions. Polymorphic variants of GPX4 (rs713041) and PON1 (rs662) genes might be a risk factor for PCOS development.
Supporting agencies: This study was funded by the Russian Science Foundation (RSF) grant № 23-15-00464.
About the Authors
R. M. Ali
Southern Federal University
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006
V. N. Prokofev
Southern Federal University
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006
S. V. Lomteva
Center for Human Reproduction and IVF
Russian Federation
Russian Federation
90, Bodraya st., Rostov-on-Don,344068
L. V. Gutnikova
Southern Federal University;
Nauka Medical Center
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006;
23A, Zagorskaya st., Rostov-on-Don, 344034
A. A. Aleksandrova
Southern Federal University;
Nauka Medical Center
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006;
23A, Zagorskaya st., Rostov-on-Don, 344034
M. N. Ammar
Southern Federal University
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006
T. P. Shkurat
Southern Federal University;
Nauka Medical Center
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006;
23A, Zagorskaya st., Rostov-on-Don, 344034
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Review
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Ali R.M., Prokofev V.N., Lomteva S.V., Gutnikova L.V., Aleksandrova A.A., Ammar M.N., Shkurat T.P. Genetic Associations between polymorphic loci in the antioxidant enzyme genes GPX4 (rs713041), GSTP1 (rs1695), and PON1 (rs662) and Polycystic Ovary Syndrome in Russian women. Medical Genetics. 2024;23(3):21-30. https://doi.org/10.25557/2073-7998.2024.03.21-30
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