Генетические ассоциации между полиморфными локусами генов ферментов антиоксидантной защиты GPX4 (rs713041), GSTP1 (rs1695) и PON1 (rs662) и синдромом поликистозных яичников у российских женщин

Введение. Синдром поликистозных яичников (СПКЯ) является распространенным и сложным эндокринологическим заболеванием, с различными молекулярными фенотипами и коморбидными состояниями. Многочисленные исследования указывают на окислительный стресс как на ключевой фактор в развитии СПКЯ.
Цель: исследовать ассоциации между полиморфными локусами генов ферментов антиоксидантной защиты GPX4 (rs713041), GSTP1 (rs1695) и PON1 (rs662) и риском развития СПКЯ.
Методы: генотипирование проводили аллель специфическим методом ПЦР в реальном времени.
Результаты. Анализ результатов генотипирования показал, что минорные аллели полиморфных локусов генов GPX4 (rs713041) и PON1 (rs662) ассоциированы с повышенным риском развития СПКЯ. В частности, наличие генотипа TT гена GPX4 (rs713041) и хотя бы одной копии аллеля С гена PON1 (rs662) было ассоциированно с повышенной предрасположенностью к СПКЯ.
Выводы. Полиморфные варианты генов GPX4 (rs713041) и PON1 (rs662) могут служить факторами риска развития СПКЯ.

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