medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2024.03.21-30medgen-2453Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHГенетические ассоциации между полиморфными локусами генов ферментов антиоксидантной защиты GPX4 (rs713041), GSTP1 (rs1695) и PON1 (rs662) и синдромом поликистозных яичников у российских женщинGenetic Associations between polymorphic loci in the antioxidant enzyme genes GPX4 (rs713041), GSTP1 (rs1695), and PON1 (rs662) and Polycystic Ovary Syndrome in Russian womenАлиР. М.AliR. M.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006

ruba.m.ali@mail.ruПрокофьевВ. Н.ProkofevV. N.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006

ЛомтеваС. В.LomtevaS. V.

344068, г. Ростов-на-Дону, ул. Бодрая, влд. 90

90, Bodraya st., Rostov-on-Don,344068

ГутниковаЛ. В.GutnikovaL. V.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42;

344034, г. Ростов-на-Дону, ул. Загорская, д. 23, к. А, офис 1

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006;

23A, Zagorskaya st., Rostov-on-Don, 344034

АлександроваА. А.AleksandrovaA. A.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42;

344034, г. Ростов-на-Дону, ул. Загорская, д. 23, к. А, офис 1

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006;

23A, Zagorskaya st., Rostov-on-Don, 344034

АммарМ. Н.AmmarM. N.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006

ШкуратТ. П.ShkuratT. P.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42;

344034, г. Ростов-на-Дону, ул. Загорская, д. 23, к. А, офис 1

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006;

23A, Zagorskaya st., Rostov-on-Don, 344034

Южный федеральный университетРоссияSouthern Federal UniversityRussian FederationЦентр репродукции человека и ЭКОРоссияCenter for Human Reproduction and IVFRussian FederationЮжный федеральный университет; Медицинский центр «Наука»РоссияSouthern Federal University; Nauka Medical CenterRussian Federation2024120720242332130Copyright © Али Р.М., Прокофьев В.Н., Ломтева С.В., Гутникова Л.В., Александрова А.А., Аммар М.Н., Шкурат Т.П., 20242024Али Р.М., Прокофьев В.Н., Ломтева С.В., Гутникова Л.В., Александрова А.А., Аммар М.Н., Шкурат Т.П.Ali R.M., Prokofev V.N., Lomteva S.V., Gutnikova L.V., Aleksandrova A.A., Ammar M.N., Shkurat T.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/2453

Введение. Синдром поликистозных яичников (СПКЯ) является распространенным и сложным эндокринологическим заболеванием, с различными молекулярными фенотипами и коморбидными состояниями. Многочисленные исследования указывают на окислительный стресс как на ключевой фактор в развитии СПКЯ.Цель: исследовать ассоциации между полиморфными локусами генов ферментов антиоксидантной защиты GPX4 (rs713041), GSTP1 (rs1695) и PON1 (rs662) и риском развития СПКЯ.Методы: генотипирование проводили аллель специфическим методом ПЦР в реальном времени.Результаты. Анализ результатов генотипирования показал, что минорные аллели полиморфных локусов генов GPX4 (rs713041) и PON1 (rs662) ассоциированы с повышенным риском развития СПКЯ. В частности, наличие генотипа TT гена GPX4 (rs713041) и хотя бы одной копии аллеля С гена PON1 (rs662) было ассоциированно с повышенной предрасположенностью к СПКЯ.Выводы. Полиморфные варианты генов GPX4 (rs713041) и PON1 (rs662) могут служить факторами риска развития СПКЯ.

Background. Polycystic ovary syndrome (PCOS) is a common and complex endocrinologic disease, with various molecular phenotypes and comorbid conditions. Numerous studies have highlighted oxidative stress as a pivotal factor in the development of PCOS.Aim: to investigate the associations between polymorphic loci of the genes of antioxidant defense enzymes GPX4 (rs713041), GSTP1 (rs1695) and PON1 (rs662) and the risk of developing PCOS.Methods. Genotyping analysis was performed by allele-specific method using real-time PCR.Results. Genotyping analysis revealed that the minor alleles of GPX4 (rs713041) and PON1 (rs662) polymorphic loci were associated with an increased risk of PCOS development. Specifically, the presence of the TT genotype of GPX4 (rs713041) and having at least one copy of the mutant allele of PON1 (rs662) were associated with elevated susceptibility to PCOS.Conclusions. Polymorphic variants of GPX4 (rs713041) and PON1 (rs662) genes might be a risk factor for PCOS development.

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The authors declare that there are no conflicts of interest present.