Partial spermatogenic arrest in two Robertsonian (14;15) translocations carriers
https://doi.org/10.25557/2073-7998.2023.04.44-48
Abstract
Balanced chromosomal rearrangements increase the risk of gametogenesis defects, infertility, aneuploidy rate and reproductive losses. The frequency of Robertsonian translocations (rob) in men with infertility, especially with severe forms of impaired spermatogenesis, is higher than in the general population, but there is lack of understanding of mechanisms of gametogenesis disorders in rob carriers. Purpose: to evaluate gametogenesis in male rob(14;15) carriers. Two infertile male rob(14;15) carriers were examined. Semen analysis and quantitative karyological analysis of immature germ cells of the ejaculate were performed. Oligoasthenoteratozoospermia caused by incomplete spermatogenic arrest at the prophase I of meiosis was diagnosed in both patients. Infertility in two examined rob(14;15) male carriers is associated with incomplete meiotic arrest resulting in decreased gamete production.
Keywords
meiosis,
meiotic arrest,
male infertility,
oligozoospermia,
Robertsonian translocations,
spermatogenesis
Supporting agencies: The work was carried out under the project “Multicenter Research Bioresource Collection “Human Reproductive Health”” No. 15.БРK.21.0008 of the Ministry of Science and Higher Education of the Russian Federation.
About the Authors
M. V. Andreeva
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechye st., Moscow, 115522
L. F. Kurilo
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechye st., Moscow, 115522
M. I. Shtaut
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechye st., Moscow, 115522
V. B. Chernykh
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechye st., Moscow, 115522
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Review
For citations:
Andreeva M.V., Kurilo L.F., Shtaut M.I., Chernykh V.B. Partial spermatogenic arrest in two Robertsonian (14;15) translocations carriers. Medical Genetics. 2023;22(4):44-48. (In Russ.) https://doi.org/10.25557/2073-7998.2023.04.44-48
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