ANRIL gene polymorphism and susceptibility to atherosclerosis
https://doi.org/10.25557/2073-7998.2023.04.32-37
Abstract
We conducted this meta-analysis to estimate associations between polymorphisms of ANRIL rs2383207 and susceptibility to atherosclerosis. A systematic literature research of Google Scholar and PubMed was performed to identify eligible studies. Overall, 12 studies were included for meta-analyses. The association was assessed by statistical odds ratio (OR) with 95% confidence interval (CI). RevMan software (Cochrane Collaboration, 5.3. Copenhagen) was used for the meta-analysis. Pooled overall analyses showed that ANRIL was associated with risk of atherosclerosis in the whole population. Further analyses by ethnicity revealed that ANRIL was associated with susceptibility to atherosclerosis in Asians and Caucasions. Our results suggest that ANRIL, might serve as genetic biomarkers of atherosclerosis. Further studies will be required to confirm the observed association.
About the Authors
S. V. Timofeeva
Southern Federal University, Academy of biology and biotechnology
Russian Federation
Russian Federation
194/1,Stachki ave, Rostov-on-Don, 344090
T. A. Sherchkova
Southern Federal University, Academy of biology and biotechnology
Russian Federation
Russian Federation
194/1,Stachki ave, Rostov-on-Don, 344090
T. P. Shkurat
Southern Federal University, Academy of biology and biotechnology
Russian Federation
Russian Federation
194/1,Stachki ave, Rostov-on-Don, 344090
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For citations:
Timofeeva S.V., Sherchkova T.A., Shkurat T.P. ANRIL gene polymorphism and susceptibility to atherosclerosis. Medical Genetics. 2023;22(4):32-37. https://doi.org/10.25557/2073-7998.2023.04.32-37
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