Signals of directed selection in the indigenous populations of Central Asia
https://doi.org/10.25557/2073-7998.2023.02.52-54
Abstract
The populations of the indigenous ethnic groups of Central Asia are of considerable interest for population genomics, due to the specificity of their gene pools, which developed under various genetic and demographic conditions. The data on directional selection signals is an important addition to the existing data on the evolution of gene pools and the mechanisms of genetic adaptation of the Eurasian population. We used an array of genotypes for 1779819 SNPs in a sample of 128 people, including 5 populations of the population of Central Asia, to search for directional selection signals using tests for extended haplotype homozygosity (nSL, iHS). For the populations of Central Asia, it was found that all the studied populations differ greatly from each other in the composition of genes that demonstrate the influence of selection. The largest number of significant signals of natural selection was found in the populations of the Kyrgyz and Uzbeks. The CUEDC1, ERC1, FAM20C, and MRC1 genes are among the genome loci that carry the most pronounced signals of directional selection in populations.
Supporting agencies: The study was supported by the Russian Science Foundation grant No. 22-64-00060, https://rscf.ru/project/22-64-00060/
About the Authors
N. A. Kolesnikov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
634050
10, Nab. r. Ushaiki
Tomsk
V. N. Kharkov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
634050
10, Nab. r. Ushaiki
Tomsk
A. A. Zarubin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
634050
10, Nab. r. Ushaiki
Tomsk
V. A. Stepanov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
634050
10, Nab. r. Ushaiki
Tomsk
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Review
For citations:
Kolesnikov N.A., Kharkov V.N., Zarubin A.A., Stepanov V.A. Signals of directed selection in the indigenous populations of Central Asia. Medical Genetics. 2023;22(2):52-54. (In Russ.) https://doi.org/10.25557/2073-7998.2023.02.52-54
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