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Variability of mitochondrial genome of the type 1 diabetes
https://doi.org/10.25557/2073-7998.2022.08.54-57
Abstract
In this work, the contribution of mitochondrial DNA (mtDNA) polymorphism to the predisposition to the development of type 1 diabetes (T1D) and its complications was studied. The study was conducted in a group of patients with T1D (n=396) and a population sample of residents of the Tomsk city (n=424). MtDNA polymorphism was studied by sequencing the hypervariable mtDNA D-loop segment and further classification of mtDNA haplotypes according to known haplogroups. The study revealed a protective effect of a rare haplogroup W with T1D (OR=0,28 (95% CI 0,09-0,85), p=0,03) and a risk effect of haplogroup T for the development of neuropathy in T1D (OR=1,72 (95% CI 1,04-2,87), p=0,048).
About the Authors
N. V. Tarasenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
N. P. Babushkina
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
T. V. Saprina
Siberian State Medical University
Russian Federation
Russian Federation
M. V. Golubenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Tarasenko N.V., Babushkina N.P., Saprina T.V., Golubenko M.V. Variability of mitochondrial genome of the type 1 diabetes. Medical Genetics. 2022;21(8):54-57. (In Russ.) https://doi.org/10.25557/2073-7998.2022.08.54-57
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