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Prevalence of FCN3 rs532781899 variants in the populations of the Krasnoyarsk region
https://doi.org/10.25557/2073-7998.2022.08.51-53
Abstract
Ficolins involved in the protecting from pathogenic microorganisms through the lectin pathway activation of the complement system. In current study data on the prevalence of genotypes and allelic variants for H-ficolin FCN3 rs532781899 in the ethnic groups of the Krasnoyarsk region (Nenets, Dolgan-Nganasans and Russians) were obtained. Genotyping was carried out using RT-PCR. The frequency of the variant del* FCN3 (+1637delC) rs532781899, leading to low concentration or complete absence of the activator of the lectin complement pathway, N-ficolin, namely, 3.6% among Russians and 0% in the Nenets, 0.8% in Dolgan-Nganasans was revealed.
About the Authors
M. V. Smolnikova
Research Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences
Russian Federation
Russian Federation
S. Yu. Tereshchenko
Research Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Smolnikova M.V., Tereshchenko S.Yu. Prevalence of FCN3 rs532781899 variants in the populations of the Krasnoyarsk region. Medical Genetics. 2022;21(8):51-53. (In Russ.) https://doi.org/10.25557/2073-7998.2022.08.51-53
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