medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2022.08.51-53medgen-2133Research ArticleКРАТКОЕ СООБЩЕНИЕBRIEF REPORTРаспределение вариантов FCN3 rs532781899 в этнических группах Красноярского краяPrevalence of FCN3 rs532781899 variants in the populations of the Krasnoyarsk regionСмольниковаМ. В.SmolnikovaM. V.smarinv@ya.ruТерещенкоС. Ю.TereshchenkoS. Yu.noemail@neicon.ruНаучно-исследовательский институт медицинских проблем Севера - обособленное подразделение ФГБНУ «Федеральный исследовательский центр «Красноярский научный центр Сибирского отделения Российской академии наук»РоссияResearch Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of SciencesRussian Federation2022081220222185153Copyright © Смольникова М.В., Терещенко С.Ю., 20222022Смольникова М.В., Терещенко С.Ю.Smolnikova M.V., Tereshchenko S.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/2133

Фиколины участвуют в защите от патогенных микроорганизмов посредством активации лектинового пути системы комплемента. В результате данного исследования получено распределение генотипов и аллельных вариантов rs532781899 гена Н-фиколина (FCN3) в этнических группах Красноярского края (ненцы, долгане-нганасаны и русские). Генотипирование проведено с использованием РТ-ПЦР. Выявлена частота варианта del* FCN3 (+1637delC) rs532781899, приводящего к низкой концентрации или полному отсутствию активатора лектинового пути комплемента Н-фиколина: среди русских 3,6%, тогда как у ненцев 0%, у долган-нганасан 0,8%.

Ficolins involved in the protecting from pathogenic microorganisms through the lectin pathway activation of the complement system. In current study data on the prevalence of genotypes and allelic variants for H-ficolin FCN3 rs532781899 in the ethnic groups of the Krasnoyarsk region (Nenets, Dolgan-Nganasans and Russians) were obtained. Genotyping was carried out using RT-PCR. The frequency of the variant del* FCN3 (+1637delC) rs532781899, leading to low concentration or complete absence of the activator of the lectin complement pathway, N-ficolin, namely, 3.6% among Russians and 0% in the Nenets, 0.8% in Dolgan-Nganasans was revealed.

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The authors declare that there are no conflicts of interest present.