Generate QR code
Open Access
Subscription Access
Molecular similarity of multifactorial and Mendelian diseases
https://doi.org/10.25557/2073-7998.2022.07.30-32
Abstract
The genetic relationship of 22 multifactorial and 6 Mendelian diseases based on data extracted from the curated DisGenNet database were studied. The coefficient of genetic «commonality» between diseases was calculated and as well as methods of clustering and prioritization were used. As a result, a pronounced common hereditary component of multifactorial diseases of various pathogenetic groups was established. The assessment of molecular similarity between Mendelian and multifactorial diseases is significantly limits due to incomplete knowledge about the contribution of genes.
About the Authors
E. Yu. Bragina
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. S. Nazarenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
V. P. Puzyrev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
References
1. Chakravarti A. Magnitude of Mendelian versus complex inheritance of rare disorders. Am J Med Genet A. 2021;185(11):3287-3293. doi:10.1002/ajmg.a.62463
2. Lupski J.R., Belmont J.W., Boerwinkle E., Gibbs R.A. Clan genomics and the complex architecture of human disease. Cell. 2011;147(1):32-43. doi:10.1016/j.cell.2011.09.008
3. Mi H., Ebert D., Muruganujan A., et al. PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API. Nucleic Acids Res. 2021;49(D1):D394-D403. doi:10.1093/nar/gkaa1106
4. Zolotareva O., Saik O.V., Königs C., et al.Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. Sci Rep. 2019;9(1):16302. doi:10.1038/s41598-019-52762-w
Review
For citations:
Bragina E.Yu., Nazarenko M.S., Puzyrev V.P. Molecular similarity of multifactorial and Mendelian diseases. Medical Genetics. 2022;21(7):30-32. (In Russ.) https://doi.org/10.25557/2073-7998.2022.07.30-32
Views:
295
Email this article 