Evaluation of the role of thrombophilia gene polymorphism in infertility in women from the Republic of Bashkortostan

Abstract

A search was made for associations of polymorphic thrombophilia gene loci with infertility and different ovarian responses to ovulation stimulation. Based on obstetric anamnesis data, 280 women were differentiated into three groups depending on the presence of a reproductive disorder: group 1 - women with infertility (n=83); Group 2 - women with habitual miscarriage (т=79). The comparison group included women with multiple term deliveries without a hereditary tendency to form blood clots (n=118). The study was conducted using real-time polymerase chain reaction. Statistical analysis was performed using the Kruskell-Wallace criteria, median test, Pearson’s χ2 test, using the Statistica 12 software package. The association of the G allele of the rs1799963 locus of the F2 gene, the G allele and the GG genotype of the rs6025 locus of the F5 gene with infertility was revealed. Associations of the G allele and the *GG genotype of the rs6046 locus of the F7 gene with a poor response to ovulation stimulation, as well as with ovarian hyperresponse, were found.