Epidemiology of gastroschisis in the Russian Federation regions for 2011-2019
https://doi.org/10.25557/2073-7998.2022.01.28-33
Abstract
Aim: to determine the population frequency of abdominal wall malformation - gastroschisis, to analyze its dynamics from 2011 to 2019, to identify risk factors according to the regional registers of congenital malformations of the Russian Federation. Methods. We used data from registers of congenital malformations in 22 constituent entities of the Russian Federation for 2011-2019. Cases of gastroschisis in newborns and in fetuses eliminated due to the detection of a defect in the prenatal period were taken into account. The frequency of the defect was calculated per 10 000 births. Results. During the analyzed period of time 896 cases of gastroschisis were registered. The majority of cases recorded in fetuses (56.6;%), 40.4% - cases of gastroschisis in livebirths and 3.0% - in stillborns. The sex ratio among the affected is 1.3M:1F. The population frequency of the defect was 2.24 (95% CI 2.10-2.40) per 10,000 births. The frequency of the defect did not change over the years of the study. Gastroschisis is more common as an isolated defect (79.1%). In 20.9%, there was a combination with other malformations. It was shown that the frequency of the defect is higher among children of mothers under the age of 20 years (frequency 8.67, 95% CI 7.38 ÷ 10.17) and less often among the offspring of women older than 35 years (1.24, 95% CI 0.97 ÷1.58). Conclusions. As a result of the study, the frequency of gastroschisis in the regions of the Russian Federation was determined, which does not change over a 9-year period. It is shown that the young age of the mother is a risk factor for the defect occurrence. The identification of such risk factors is important to improve the effectiveness of preventive measures.
About the Authors
N. S. Demikova
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University; Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
M. A. Podolnaya
Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
E. E. Zayaeva
Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Demikova N.S., Podolnaya M.A., Zayaeva E.E. Epidemiology of gastroschisis in the Russian Federation regions for 2011-2019. Medical Genetics. 2022;21(1):28-33. (In Russ.) https://doi.org/10.25557/2073-7998.2022.01.28-33
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