EFFICIENCY OF FETAL CHROMOSOMAL ABNORMALITIES RISK PREDICTION IN IVF PREGNANCIES
https://doi.org/10.1234/XXXX-XXXX-2015-1-13-19
Abstract
We analyzed the results of prenatal screening in women achieved pregnancy through IVF. There were examined 366 pregnant women: 93 twins (one of them monochorionic), 1 triplet and 262 singleton pregnancies. Integrated risk assessment was based on ultrasound and biochemical markers and 1% of threshold the high risk group consisted of 12 fetuses (2.5%). Invasive diagnostic procedure was performed in 7 pregnancies, 4 cases with chromosomal abnormalities were found, including 3 case of trisomy 21, and 1 case of trisomy 18. The total frequency of chromosomal abnormalities was 1 of 91 (1,08%) cases, andtrisomy21 —1 of 114cases. The integrated risk assessment of chromosomal abnormalities in IVF pregnancies has high efficacy and sensitivity. The median value definition for the biochemical indicators and a taking into account population and reproductive technology-related peculiarity are desirable to decrease the number of false-positive results.
About the Author
A. Sh. Latypov
Russian Medical Academy of Postgraduate Education Studies
Russian Federation
Russian Federation
Barrikadnaya str., 2/1-1, Moscow, 123995, Russia
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Review
For citations:
Latypov A.Sh. EFFICIENCY OF FETAL CHROMOSOMAL ABNORMALITIES RISK PREDICTION IN IVF PREGNANCIES. Medical Genetics. 2015;14(1):13-19. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2015-1-13-19
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