Structural features of the gene SIRT1 in residents of the Siberian region
https://doi.org/10.25557/2073-7998.2021.06.27-32
Abstract
Depression is a multifactorial mental disorder that is one of the main causes of disability and leads to suicide in 15% of cases. An active search for the genetic component of depression has identified a number of candidate genes that correlate with depression. Recent studies have demonstrated the association of a number of polymorphic variants of the SIRT1 gene with depression. At the same time, the specificity of the distribution of polymorphic variants in the SIRT1 gene among different populations remains unexplored, which may be significant in the analysis of associations. We have studied the structure of the coding part of the SIRT1 gene in the populations of Yakuts, Tuvans, and residents of Novosibirsk. Depending on the ethnic group, there was a change in the frequency of occurrence of polymorphic variants.
About the Authors
D. A. Berdyugina
Scientific-Research Institute of Neurosciences and Medicine
Russian Federation
Russian Federation
A. N. Savostyanov
Scientific-Research Institute of Neurosciences and Medicine; Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
D. V. Bazovkina
Scientific-Research Institute of Neurosciences and Medicine; Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
S. P. Kovalenko
Federal Research Center of Fundamental and Translational Medicine
Russian Federation
Russian Federation
L. I. Aftanas
Scientific-Research Institute of Neurosciences and Medicine
Russian Federation
Russian Federation
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Review
For citations:
Berdyugina D.A., Savostyanov A.N., Bazovkina D.V., Kovalenko S.P., Aftanas L.I. Structural features of the gene SIRT1 in residents of the Siberian region. Medical Genetics. 2021;20(6):27-32. (In Russ.) https://doi.org/10.25557/2073-7998.2021.06.27-32
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