Genetic markers of fibrogenesis in determining susceptibility to chronic hepatitis C virus infection

The study included patients with chronic viral hepatitis C (chronic HCV) (n = 184) and a population-based sample of Tomsk residents (n = 285). Genotyping of 58 polymorphic variants was performed using mass spectrometry on the Sequenom MassARRAY ® (USA). Statistical data processing was carried out in the software environment R. Patients with chronic HCV have higher frequency of ‘A’ allele of the MMP3 gene variant rs650108 (OR = 1,74, 95%CI: 1,25-2,42; p = 0,0001), and ‘C’ allele of the KIAA1462 gene variant rs3739998 (OR = 1,33, 95%CI: 1,01-1,75; p = 0,044) and a lower frequency of ‘T’ allele of the LIG1 gene variant rs20579 (OR = 0,55, 95%CI: 0,36-0,84; p = 0,004), ‘G’ allele of the ADAMDEC1 gene variant rs3765124 (OR = 0,68, 95%CI: 0,51-0,84; p = 0,006) and ‘C’ allele of the ITGB5 gene variant rs1007856 (OR = 0,75, 95%CI: 0,57-0,99; p = 0,045) compared with the controls. The following genotypes are predisposing to the development of chronic HCV: ‘CC’ of the rs10087305 variant (OR = 5,83, 95%CI: 1,74-19,02; p = 0,002) and ‘AA’ of the rs3765124 variant (OR = 1,78, 95%CI: 1,16-8,46; p = 0,008) of the ADAMDEC1 gene; ‘AA’ of the MMP3 gene variant rs679620 (OR = 2,40, 95%CI: 1,40-4,12; p = 0,001); ‘TT’ of the ITGB5 gene variant rs1007856 (OR = 1,74, 95%CI: 1,10-2,73; р = 0,015); ‘CC’ of the LIG1 gene variant rs20579 (OR = 1,92, 95%CI: 1,18-3,12; p = 0,007); ‘CC’ of the KIAA1462 gene variant rs3739998 (OR = 1,89, 95%CI: 1,16-3,10; p = 0,009). Therefore, in susceptibility to chronic HCV contribute genes of extracellular matrix metabolism regulation ( ADAMDEC1; MMP3; ITGB5 ), directly affecting the processes of fibrogenesis, as well as genes responsible for the endothelial function ( KIAA1462 ) and DNA repair ( LIG1 ).

хронический вирусный гепатит С (ХВГС), гены ADAM-подобного дицеклина 1 (ADAMDEC1), металлопротеазы 3 (ММР3), интегрина бета 5 (ITGB5), лигазы 1 (LIG1), KIAA146, chronic viral hepatitis C (chronic HCV), ADAM-Like Decysin 1 gene (ADAMDEC1), metalloprotease 3 gene (ММР3), integrin beta 5 gene (ITGB5), ligase 1 gene (LIG1), KIAA1462

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