Genetic factors in development of intracranial arterial aneurisms
Abstract
Background. Management of intracranial arterial aneurysms remains one of the most important problems of the vascular neurosurgery because of high morbidity and mortality rate. According to recent data, the prevalence of Intracranial Aneurysms (IA) is much higher, than was thought before. Etiology and pathogenesis of IA remains obscure. Such recognized factors as arterial hypertension, age and smoking cannot fully explain aneurysm formation and clinical course. Increasing evidence of familial aneurysms and high incidence of IA in such families and in patients with congenital connective tissue disease together with modern possibilities in genetic studies led to investigations of the genetic origin of IA. The Aim of the study was to summaries what is presently known about genetics of IA. Results. Analysis of the literature showed an increase in the number of publications and volumes of testing data in the study of genetic factors in the etiology of aneurysms. More than 20 loci and genes, associated with IA, are identified. Some of them are confirmed in independent investigations. Loci with a high degree of reliability are registered in OMIM. Genetic heterogeneity in different population groups is shown. Attempts are made to link identified genetic changes with the clinical course of IA. Further studies are needed to find IA susceptibility genes and there interaction with known risk factors, that will in future lead to new therapeutic opportunities.
About the Authors
O. B. Belousova
The Scientific Research Neurosurgery Institute named after the academician Nikolay Nilovich Burdenko
Russian Federation
Russian Federation
V. A. Gorozhanin
The Scientific Research Neurosurgery Institute named after the academician Nikolay Nilovich Burdenko
Russian Federation
Russian Federation
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Belousova O.B., Gorozhanin V.A. Genetic factors in development of intracranial arterial aneurisms. Medical Genetics. 2016;15(12):3-13. (In Russ.)
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