Molecular mechanisms of imprinted gene disturbance in the embryonic development pathology and recurrent pregnancy loss
https://doi.org/10.25557/2073-7998.2020.11.79-80
Abstract
It was found that disturbances of embryonic development are accompanied by multi-locus imprinting disturbance (MLID), the frequency of which is increased in placental tissues of spontaneous abortions from women with recurrent pregnancy loss. It is shown that MLID are accompanied by NLRP7 gene mutations in spontaneous abortions from women with recurrent pregnancy loss, and parents are heterozygous carriers of these mutations.
About the Authors
E. A. Sazhenova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
I. N. Lebedev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
References
1. Саженова Е.А., Лебедев И.Н. Молекулярные механизмы нарушений импринтированных генов при патологии пре- и постнатального развития. Медицинская генетика. 2018;17(11):3-6.
Review
For citations:
Sazhenova E.A., Lebedev I.N. Molecular mechanisms of imprinted gene disturbance in the embryonic development pathology and recurrent pregnancy loss. Medical Genetics. 2020;19(11):79-80. (In Russ.) https://doi.org/10.25557/2073-7998.2020.11.79-80
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