Transcriptomics of placental tissue: identification of molecular mechanisms and measures for targeted therapy of grate obstetric syndromes

Abstract

It is shown that the key pathogenetic mechanisms of grate obstetric syndromes (GOS) are associated with impaired placentation. The aim of the work was to search for new genetic markers of GOS on the basis of integrative analysis of genome-wide expression profiling data. We found that the transcriptional activity of 64 genes changes in at least two GOS diseases. The significant role of disturbance of intercellular interactions and regulation of protein modification in placental tissue during the development of the pregnancy complications is shown. Master regulators that are potential therapeutic targets have been identified.