Co-expression network analysis of placental transcriptome as the basis for searching signal ways and preeclampsia biomarkers

Abstract

The problem of prevention and early diagnosis of preeclampsia continues to be one of the leading in obstetrics. It`s a major problem that contributes substantially to maternal and perinatal morbidity and mortality worldwide . Gene expression contributes significantly to the pathogenesis of placental diseases. Traditional methods of studying gene expression are based on the search of differentially expressed genes in a disease, but this approach considers genes in isolation. Coexpression analysis describes the genes involved in the unified biological pathways of the pathological process and also allows you to select in each of the clusters the most functionally significant gene in the network - the hub gene.