Analysis of the genetic architecture of preeclampsia in the context of evolutionary medicine
https://doi.org/10.25557/2073-7998.2020.11.69-70
Abstract
In this research first applied evolutionary approach to study of the PE genetics architecture via the regulatory polymorphic variants (rSNPs) of differentially expressed genes (DEG), identified by analysis of the transcriptome in placental tissue. The results demonstrate а significant role of 10 rSNP 8 DEG and their adaptive changes at the macroevolutionary and/or microevolutionary level in the formation of hereditary predisposition to PE in Russians and Yakuts.
About the Authors
V. N. Serebrova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
E. A. Trifonova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
V. A. Stepanov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
References
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Review
For citations:
Serebrova V.N., Trifonova E.A., Stepanov V.A. Analysis of the genetic architecture of preeclampsia in the context of evolutionary medicine. Medical Genetics. 2020;19(11):69-70. (In Russ.) https://doi.org/10.25557/2073-7998.2020.11.69-70
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