The effect of new water-soluble derivatives of C60 fullerene having identical substituents and one substitution CL→ME on gene expression and the activity of transcription factors NRF2 and NFkB
https://doi.org/10.25557/2073-7998.2020.11.58-60
Abstract
With the use of new nanocompounds, in particular, derivatives of fullerene C60, the likelihood of human contact with them increases. It has been shown that water-soluble derivatives of fullerene can affect the transcriptional activity of genes in human embryonic fibroblasts of the lungs (PLEC). Activation of the transcription factor NFkB (nuclear factor kappa-light-chain-enhancer of activated B cells) induces processes aimed at cell survival, as well as the development of a pro-inflammatory response. The expression of genes that provide protection against stress at the cellular level is triggered by a transcription factor, NRF2 (nuclear factor [erythroid-derived 2] -like factor 2). The interaction between NFkB and NRF2 is mainly antagonistic. The search for new compounds that selectively activate the transcription factor NFkB and NRF2 remains an urgent task of modern medicine.
About the Authors
E. A. Savinova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
E. S. Ershova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
I. V. Rodionov
Research Centre for Medical Genetics
Russian Federation
Russian Federation
N. N. Veiko
Research Centre for Medical Genetics
Russian Federation
Russian Federation
O. A. Kraevaya
Skolkovo Institute of Science and Technology; Institute of Problems of Chemical Physics of the Russian Academy of Sciences
Russian Federation
Russian Federation
P. A. Troshin
Skolkovo Institute of Science and Technology; Institute of Problems of Chemical Physics of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. V. Kostyuk
Research Centre for Medical Genetics
Russian Federation
Russian Federation
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Review
For citations:
Savinova E.A., Ershova E.S., Rodionov I.V., Veiko N.N., Kraevaya O.A., Troshin P.A., Kostyuk S.V. The effect of new water-soluble derivatives of C60 fullerene having identical substituents and one substitution CL→ME on gene expression and the activity of transcription factors NRF2 and NFkB. Medical Genetics. 2020;19(11):58-60. (In Russ.) https://doi.org/10.25557/2073-7998.2020.11.58-60
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