Genotoxicity of cationic lipopeptide nanoparticles
Abstract
A single and repeated doses of nanoparticles caused DNA damage in the liver, lung and kidney of mice as well as in the in vitro comet assay on bone marrow cells. No statistically significant increase in the percentage of cells with chromosomal aberrations was observed in mice treated with nanoparticles after a single or repeated injection.
About the Authors
E. A. Anisina
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
A. K. Zhanataev
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
A. A. Lisitsyn
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
I. P. Shilovskiy
NRC Institute of Immunology of FMBA of Russia
Russian Federation
Russian Federation
O. O. Koloskova
NRC Institute of Immunology of FMBA of Russia
Russian Federation
Russian Federation
M. R. Khaitov
NRC Institute of Immunology of FMBA of Russia
Russian Federation
Russian Federation
A. D. Durnev
Zakusov Research Institute of Pharmacology
Russian Federation
Russian Federation
Review
For citations:
Anisina E.A., Zhanataev A.K., Lisitsyn A.A., Shilovskiy I.P., Koloskova O.O., Khaitov M.R., Durnev A.D. Genotoxicity of cationic lipopeptide nanoparticles. Medical Genetics. 2020;19(9):65-66. (In Russ.)
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