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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medgen-1711</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Генотоксичность катионных липопептидных наночастиц</article-title><trans-title-group xml:lang="en"><trans-title>Genotoxicity of cationic lipopeptide nanoparticles</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анисина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Anisina</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">anisinalena@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жанатаев</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhanataev</surname><given-names>A. K.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лисицын</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lisitsyn</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шиловский</surname><given-names>И. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Shilovskiy</surname><given-names>I. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колоскова</surname><given-names>О. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Koloskova</surname><given-names>O. O.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хаитов</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Khaitov</surname><given-names>M. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дурнев</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Durnev</surname><given-names>A. D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «НИИ фармакологии имени В.В. Закусова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Zakusov Research Institute of Pharmacology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ ГНЦ Институт иммунологии ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>NRC Institute of Immunology of FMBA of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>11</month><year>2020</year></pub-date><volume>19</volume><issue>9</issue><fpage>65</fpage><lpage>66</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Анисина Е.А., Жанатаев А.К., Лисицын А.А., Шиловский И.Р., Колоскова О.О., Хаитов М.Р., Дурнев А.Д., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Анисина Е.А., Жанатаев А.К., Лисицын А.А., Шиловский И.Р., Колоскова О.О., Хаитов М.Р., Дурнев А.Д.</copyright-holder><copyright-holder xml:lang="en">Anisina E.A., Zhanataev A.K., Lisitsyn A.A., Shilovskiy I.P., Koloskova O.O., Khaitov M.R., Durnev A.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1711">https://www.medgen-journal.ru/jour/article/view/1711</self-uri><abstract><p>Наночастицы при однократном и многократном введении увеличивают уровень повреждений ДНК в легких, печени и почках мышей, а также в клетках костного мозга in vitro. В условиях однократного и многократного введения наночастицы не индуцируют хромосомные аберрации в клетках костного мозга мышей.</p></abstract><trans-abstract xml:lang="en"><p>A single and repeated doses of nanoparticles caused DNA damage in the liver, lung and kidney of mice as well as in the in vitro comet assay on bone marrow cells. No statistically significant increase in the percentage of cells with chromosomal aberrations was observed in mice treated with nanoparticles after a single or repeated injection.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>катионные липопептидные наночастицы</kwd><kwd>ДНК-кометы</kwd><kwd>генотоксичность</kwd><kwd>хромосомные аберрации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cationic lipopeptide nanoparticles</kwd><kwd>genotoxicity</kwd><kwd>comet assay</kwd><kwd>chromosome aberrations</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
